Search results for "Colon drug delivery"

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Photocrosslinking of dextran and polyaspartamide derivatives: a combination suitable for colon-specific drug delivery.

2007

Abstract The aim of this study was to prepare and characterize novel hydrogels with polysaccharide–polyaminoacid structure, able to undergo an enzymatic hydrolysis in the colon and potentially useful for treating inflammatory bowel diseases (IBD). Starting materials were methacrylated dextran (DEX-MA) and methacrylated α,β-poly(N-2-hydroxyethyl)- dl -aspartamide (PHM). These polymers were photocrosslinked by exposure of their aqueous solutions at 313 nm without photoinitiators. Different samples, shaped as microparticles, were obtained as a function of polymer concentration and irradiation time. FT-IR analysis confirmed the occurrence of a co-crosslinking between DEX-MA and PHM in all exper…

alpha; beta-poly(n-2-hydroxyethyl)-dl-aspartamide; biodegradable hydrogels; colon drug delivery; dextran; photocrosslinking; α; β-poly(n-2-hydroxyethyl)-dl-aspartamidealphaCell SurvivalColonPhotochemistryDrug CompoundingαPharmaceutical ScienceDosage formchemistry.chemical_compoundDrug StabilityEnzymatic hydrolysismedicineCell AdhesionOrganic chemistryHumansParticle Sizeβ-poly(n-2-hydroxyethyl)-dl-aspartamideDrug CarriersChromatographyDextranaseAqueous solutionChemistryHydrolysisbiodegradable hydrogelstechnology industry and agriculturecolon drug deliveryBeclomethasoneMucinsDextransHydrogelsHydrogen-Ion ConcentrationDextranCross-Linking Reagentsbeta-poly(n-2-hydroxyethyl)-dl-aspartamidedextranDrug deliverySelf-healing hydrogelsMethacrylatesSwellingmedicine.symptomphotocrosslinkingCaco-2 CellsPeptidesJournal of controlled release : official journal of the Controlled Release Society
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New polysaccharide-polyaminoacid hydrogels: a suitable strategy for colon-specific drug delivery

2007

The aim of this study was to prepare and characterize novel hydrogels with polysaccharide–polyaminoacid structure, able to undergo an enzymatic hydrolysis in the colon and potentially useful for treating inflammatory bowel diseases (IBD). Starting materials were methacrylated dextran (DEX-MA) and methacrylated α,β-poly(N-2-hydroxyethyl)-DL-aspartamide (PHM). These polymers were photocrosslinked by exposure of their aqueous solutions at 313 nm without photoinitiators. Different samples, shaped as microparticles, were obtained as a function of polymer concentration and irradiation time. FT-IR analysis confirmed the occurrence of a co-crosslinking between DEX-MA and PHM in all experimental con…

αβ-Poly(N-2-hydroxyethyl)-DL-aspartamideBiodegradable hydrogelColon drug deliveryDextranPhotocrosslinking
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